CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Reductions in Serum Hepatitis B Surface Antigen (HBsAg) Occur in Parallel with Reductions in Intrahepatic HBV Covalently Closed Circular (ccc) DNA in Chronic Hepatitis B (CH-B) Patients Receiving Adefovir Dipivoxil (ADV)
DOI 10.1055/s-2004-831751
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Autor:innenK Wursthorn, P Buggisch, F Metzler, B Werle, F Zoulim, SA Locarnini, W Delaney, S Xiong, H Greten, J Petersen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2004
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: We previously demonstrated that 48 weeks of ADV therapy reduced intrahepatic HBV cccDNA by a median of 86% (p=0.002 vs. placebo) in CH-B patients and was correlated with significant reductions in serum and intracellular HBV DNA (HEPATOLOGY 2002;36: 296A). Since HBV cccDNA is the transcriptional template for HBsAg, we investigated whether reductions in cccDNA translated into significant reductions in se…
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Zitierempfehlung
K Wursthorn, P Buggisch, F Metzler, B Werle, F Zoulim, SA Locarnini, W Delaney, S Xiong, H Greten, J Petersen (2004) Reductions in Serum Hepatitis B Surface Antigen (HBsAg) Occur in Parallel with Reductions in Intrahepatic HBV Covalently Closed Circular (ccc) DNA in Chronic Hepatitis B (CH-B) Patients Receiving Adefovir Dipivoxil (ADV). Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-2004-831751
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