CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Development of a non-replicative, single shot DNA-based vaccine expressing all hepatitis B viral antigens
DOI 10.1055/s-2004-831754
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Nachweis in CareLit
Autor:innenM Geißler, S Gaiser, CF Grimm, K Endrulat, HE Blum
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: The activity of a broad based cellular immune response to different HBV antigens is an important factor contributing to virus elimination. Our aim was to develop a single shot DNA vaccine expressing all HBV antigens but lacking replication. Therefore, a CMV-promoter based plasmid producing a HBV pregenome lacking the first 43 nt resulting in a mutated epsilon-signal and subsequently a defective pregeno…
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Zitierempfehlung
M Geißler, S Gaiser, CF Grimm, K Endrulat, HE Blum (2004) Development of a non-replicative, single shot DNA-based vaccine expressing all hepatitis B viral antigens. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-2004-831754
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