CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Molecular cloning and characterization of Mouse Ntcp promoter: Potent activation by HNF–4a supporting HNF–4 null mice phenotype as well as modest activation by HNF–1a
DOI 10.1055/s-2004-831785
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Autor:innenA Geier, C Gartung, FJ Suchy, CG Dietrich, F Lammert, S Matern, M Ananthanarayanan
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2004
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Sodium taurocholate co-transporting polypeptide (Ntcp) is the major uptake system for conjugated bile acids. Cholestasis leads to downregulation of Ntcp mRNA and protein involving a decrease in nuclear HNF–1 levels in rats. Whether similar mechanisms operate in the regulation of mouse Ntcp gene is unknown. Aim: To clone and functionally characterize mouse Ntcp promoter. Methods: A 129/SV mouse lambda g…
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Zitierempfehlung
A Geier, C Gartung, FJ Suchy, CG Dietrich, F Lammert, S Matern, M Ananthanarayanan (2004) Molecular cloning and characterization of Mouse Ntcp promoter: Potent activation by HNF–4a supporting HNF–4 null mice phenotype as well as modest activation by HNF–1a. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-2004-831785
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