CareLit · DOI-Nachweis · Klinische Neurophysiologie
Improved Helper-Dependent Adenoviral Vectors for High-Level, Neuron-Restricted Gene Transfer into the CNS
DOI 10.1055/s-2004-832015
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Hermening, S Kügler, M Bähr, S Isenmann
ZeitschriftKlinische Neurophysiologie
Ausgabe08/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Adenoviral vectors (Ad) possess a number of attributes which favour their use for CNS gene delivery, e.g., their ability to infect post-mitotic tissues. However, the widespread distribution of the cellular receptor for Ad, the Coxsackie/adenovirus receptor (CAR), allows adenoviral vectors to infect a broad range of cells in the host, thus limiting cell-type specificity for gene transfer in the CNS. Also, the safety…
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Zitierempfehlung
S Hermening, S Kügler, M Bähr, S Isenmann (2004) Improved Helper-Dependent Adenoviral Vectors for High-Level, Neuron-Restricted Gene Transfer into the CNS. Klinische Neurophysiologie (08). https://doi.org/10.1055/s-2004-832015
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