CareLit · DOI-Nachweis · Klinische Neurophysiologie
Prevention of Alzheimer's Associated Aβ-Aggregation by Rationally Designed Non-Peptidic β-Sheet Ligands
DOI 10.1055/s-2004-832139
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Riesner, P Rzepecki, L Nagel-Steger, S Feuerstein, U Linne, O Molt, R Zadmard, K Aschermann, M Wehner, T Schrader
ZeitschriftKlinische Neurophysiologie
Ausgabe08/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
A new concept is introduced for the rational design of β-sheet ligands, which prevent protein aggregation: oligomeric acylated aminopyrazoles with a DAD hydrogen bond pattern complementary to that of a β-sheet efficiently block the solvent-exposed β-sheet portions in Aβ(1–40) and thereby prevent the formation of insoluble protein aggregates. Density gradient centrifugation revealed that, in the initial phase, the si…
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Zitierempfehlung
D Riesner, P Rzepecki, L Nagel-Steger, S Feuerstein, U Linne, O Molt, R Zadmard, K Aschermann, M Wehner, T Schrader (2004) Prevention of Alzheimer's Associated Aβ-Aggregation by Rationally Designed Non-Peptidic β-Sheet Ligands. Klinische Neurophysiologie (08). https://doi.org/10.1055/s-2004-832139
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