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Axonal damage in patients with early multiple sclerosis: disease stage related changes of Tau protein level in cerebrospinal fluid

J Brettschneider, M Maier, S Arda, A Claus, S Süssmuth, J Kassubek, H Tumani · Aktuelle Neurologie · Ausgabe 09/2004

DOI 10.1055/s-2004-832946

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Autor:innenJ Brettschneider, M Maier, S Arda, A Claus, S Süssmuth, J Kassubek, H Tumani
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben

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Background: Axonal damage has been proposed as the major morphological substrate of permanent clinical disability in multiple sclerosis (MS). Tau protein (tau), a phosphorylated microtubule-associated protein localised in neuronal axons, may serve as a biochemical surrogate to evaluate axonal loss in vivo. We intended to determine the extent of axonal degeneration in different stages and clinical subtypes of MS by i…

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J Brettschneider, M Maier, S Arda, A Claus, S Süssmuth, J Kassubek, H Tumani (2004) Axonal damage in patients with early multiple sclerosis: disease stage related changes of Tau protein level in cerebrospinal fluid. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-832946

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