CareLit · DOI-Nachweis · Aktuelle Neurologie
Mitochondrial impairment in patients and asymptomatic gene carriers of Huntington's disease
DOI 10.1055/s-2004-832980
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Autor:innenJ Andrich, C Saft, J Zange, K Müller, K Lindenberg, B Landwehrmeyer, M Vorgerd, PK Kraus, H Przuntek, L Schöls
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Huntington's disease (HD) is clinically characterized by a progressive movement disorder, cognitive decline and mood disturbance. HD is caused by a CAG repeat expansion in the IT-15 gene resulting in an expanded polyglutamine stretch in the mutant huntingtin protein. The mechanism how polyglutamine expansions cause neurodegeneration is still unknown. Several lines of evidence point to impaired energy met…
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Zitierempfehlung
J Andrich, C Saft, J Zange, K Müller, K Lindenberg, B Landwehrmeyer, M Vorgerd, PK Kraus, H Przuntek, L Schöls (2004) Mitochondrial impairment in patients and asymptomatic gene carriers of Huntington's disease. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-832980
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