CareLit · DOI-Nachweis · Aktuelle Neurologie
Activation of p21WAF1/CIP1 by erythropoietin prevents neuronal cell death and mediates ischemic preconditioning in primary cortical neurons
DOI 10.1055/s-2004-833033
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Ruscher, N Isaev, U Dirnagl, A Meisel
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Rational: Ischemic preconditioning (IP) triggers adaptive mechanisms in tissues or isolated cells and induces tolerance against an otherwise lethal ischemia. Gene expression profiling revealed an upregulation of the cell cycle inhibitor p21WAF1/CIP1 (p21) on mRNA-level following IP in rat primary cortical neurons and mouse brains. In previous studies we have identified erythropoietin (EPO) as an essential mediator o…
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Zitierempfehlung
K Ruscher, N Isaev, U Dirnagl, A Meisel (2004) Activation of p21WAF1/CIP1 by erythropoietin prevents neuronal cell death and mediates ischemic preconditioning in primary cortical neurons. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833033
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