CareLit · DOI-Nachweis · Aktuelle Neurologie
Topiramate modulates recombinant GABA(A) receptors by a nonbenzodiazepine mechanism
DOI 10.1055/s-2004-833115
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Nachweis in CareLit
Autor:innenN Müller, K Krampfl, J Bufler
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Purpose: The study investigates the mechanism of action of topiramate at recombinant GABA(A) receptor subtypes. Methods: HEK293 cells were transiently transfected with cDNAs of different GABA(A) receptor subunits. Alpha1beta2gamma2, alpha6beta2gamma2, alpha6beta2delta, and alpha6beta2 GABA(A) receptor subtypes were functionally expressed in HEK293 cells. Topiramate enhancement of GABA (1–10 microM)-evoked currents w…
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Zitierempfehlung
N Müller, K Krampfl, J Bufler (2004) Topiramate modulates recombinant GABA(A) receptors by a nonbenzodiazepine mechanism. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833115
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