CareLit · DOI-Nachweis · Aktuelle Neurologie
Beta-secretase (BACE) and GGA1 interaction in cells is dependent on BACE phosphorylation
DOI 10.1055/s-2004-833262
Bibliografische Angaben
Nachweis in CareLit
Autor:innenCAF von Arnim, MM Tangredi, ID Peltan, BM Lee, MC Irizarry, BT Hyman
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Amyloid-beta peptide, which accumulates in senile plaques in Alzheimer's disease (AD), is derived from the amyloid precursor protein (APP)by cleavage of Beta-secretase (BACE), transmembrane aspartic proteinase and consequently Gamma-secretase. Since a majority of BACE cleavage activity occurs in endosomes, signals regulating its trafficking to these compartments are important to understand AD pathogenesis. Golgi-loc…
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Zitierempfehlung
CAF von Arnim, MM Tangredi, ID Peltan, BM Lee, MC Irizarry, BT Hyman (2004) Beta-secretase (BACE) and GGA1 interaction in cells is dependent on BACE phosphorylation. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833262
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