CareLit · DOI-Nachweis · Aktuelle Neurologie
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists modulate immunostimulated processing of APP through regulation of beta-secretase (BACE)
DOI 10.1055/s-2004-833264
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Nachweis in CareLit
Autor:innenI Dewachter, E Rosen, G Landreth, T Willson, T Klockgether, F Van Leuven, M Heneka
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Prolonged intake of non-steroidal-anti-inflammatory drugs (NSAIDs) reduces the risk for Alzheimer's disease (AD). To determine the mechanisms by which inflammation affects AD and how NSAIDs protect against it, we stimulated N2a neuroblastoma cells stably transfected with amyloid precusor protein (APP) with pro-inflammatory cytokines, which increased the secretion of amyloid-beta (A-beta) and APP ectodomain. Addition…
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Zitierempfehlung
I Dewachter, E Rosen, G Landreth, T Willson, T Klockgether, F Van Leuven, M Heneka (2004) Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists modulate immunostimulated processing of APP through regulation of beta-secretase (BACE). Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833264
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