CareLit · DOI-Nachweis · Aktuelle Neurologie
Chaperone mediated degradation of aggregated alpha synuclein
DOI 10.1055/s-2004-833268
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Autor:innenJ Klucken, Y Shin, PJ Mclean, BT Hyman
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aggregation and cytotoxicity of misfolded alpha-synuclein is postulated to be crucial in the disease process of neurodegenerative disorders such as Parkinson's disease and dementia with Lewy bodies. Overexpression of C-terminally modified alpha-synuclein and synphilin-1 produce intracellular alpha-synuclein aggregates in human H4 cells (McLean et al., Neuroscience, 2001). We have previously demonstrated that overexp…
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Zitierempfehlung
J Klucken, Y Shin, PJ Mclean, BT Hyman (2004) Chaperone mediated degradation of aggregated alpha synuclein. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833268
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