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Monocyte-derived HLA-G, a strong inhibitor of autologous CD4 T-cell activation, is upregulated by interferon-β in vitro and in vivo: rationale for the therapy of multiple sclerosis?

M Mitsdörffer, B Schreiner, BC Kieseier, O Neuhaus, J Dichgans, HP Hartung, M Weller, H Wiendl · Aktuelle Neurologie · Ausgabe 09/2004

DOI 10.1055/s-2004-833324

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Autor:innenM Mitsdörffer, B Schreiner, BC Kieseier, O Neuhaus, J Dichgans, HP Hartung, M Weller, H Wiendl
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Objective: To investigate the role of monocyte-derived HLA-G in the immune-regulatory processes of MS and its implications for current immune-modulatory therapies. Background: HLA-G is a non-classical MHC molecule that has been attributed chiefly negative immune regulatory functions. Antigen presenting cells are important for the maintenance of immune tolerance and considered to play a critical role in promoting the…

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M Mitsdörffer, B Schreiner, BC Kieseier, O Neuhaus, J Dichgans, HP Hartung, M Weller, H Wiendl (2004) Monocyte-derived HLA-G, a strong inhibitor of autologous CD4 T-cell activation, is upregulated by interferon-β in vitro and in vivo: rationale for the therapy of multiple sclerosis?. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833324

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