CareLit · DOI-Nachweis · Aktuelle Neurologie
Single-cell PCR analysis of the immunoglobulin heavy chain CDR3 region for the diagnosis of leptomeningeal involvement of B-cell malignancies
DOI 10.1055/s-2004-833343
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Haas, A Hug, M Vogt-Schaden, H Goldschmidt, B Storch-Hagenlocher, B Wildemann
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: The diagnosis of leptomeningeal B-cell malignancies is based on identification of malignant B-cells in the CSF. Molecular analysis of B-cell clonality in CSF samples via amplification and size determination of the highly diverse CDR3-IgH region is a useful approach to distinguish neoplastic from reactive B-cell responses within the CSF and supplements standard diagnostic procedures such as cytology, immu…
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Zitierempfehlung
J Haas, A Hug, M Vogt-Schaden, H Goldschmidt, B Storch-Hagenlocher, B Wildemann (2004) Single-cell PCR analysis of the immunoglobulin heavy chain CDR3 region for the diagnosis of leptomeningeal involvement of B-cell malignancies. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833343
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