CareLit · DOI-Nachweis · Aktuelle Neurologie
Mechanisms of excitotoxicity: AMPA-mediated calcium dynamics in spinal motoneurons
DOI 10.1055/s-2004-833365
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Jaeckel, K Haastert, P Claus, C Grothe, R Dengler, J Bufler, J Grosskreutz
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: ALS is a neurodegenerative disease, which is characterized by rapid loss of motoneurons. Chronic AMPA- receptor mediated excitotoxicity seems to play a major role in the pathogenetic process, but the mechanisms of the selective vulnerability of motoneurons are still unknown. Apoptosis like degeneration of motoneurons after excitotoxic insults can be imitated in vitro, proposing extensive mitochondrial…
Zitieren
Zitierempfehlung
M Jaeckel, K Haastert, P Claus, C Grothe, R Dengler, J Bufler, J Grosskreutz (2004) Mechanisms of excitotoxicity: AMPA-mediated calcium dynamics in spinal motoneurons. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833365
Mit CareLit weiterarbeiten