CareLit · DOI-Nachweis · Aktuelle Neurologie
Excitatory amino acid transporter 3 and the glutamate/cystine antiporter system Xc- cooperatively protect neuronal HT22 cells from oxidative glutamate toxicity
DOI 10.1055/s-2004-833373
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Nachweis in CareLit
Autor:innenM Klein, A Methner, J Lewerenz
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Oxidative stress plays a role in many neurological diseases such as Alzheimer's and Parkinson's disease, or stroke. Oxidative glutamate toxicity in the mouse hippocampal cell line HT22 serves as a model system for neuronal death in response to oxidative stress, in which excess extracellular glutamate inhibits the import of cystine via the glutamate/cystine antiporter system Xc-. Cystine is a crucial constituent for…
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Zitierempfehlung
M Klein, A Methner, J Lewerenz (2004) Excitatory amino acid transporter 3 and the glutamate/cystine antiporter system Xc- cooperatively protect neuronal HT22 cells from oxidative glutamate toxicity. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833373
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