CareLit · DOI-Nachweis · Aktuelle Neurologie
Blood flow independent effects of rt-PA in a model of permanent cerebral ischemia: deterioration of ischemia induced cell death
DOI 10.1055/s-2004-833378
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Nachweis in CareLit
Autor:innenO Crome, R Sandau, F Agdas, M Bähr, J Weise
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Recombinant tissue plasminogen activator (rt-PA) is the only approved drug for the therapy of acute ischemic stroke. However there is raising evidence that endogenous t-PA acts as a mediator of neuronal damage in different models of neuronal cell death. Regarding its use in stroke therapy a reduced infarct volume was found in t-PA-knockout mice compared to wild type mice in transient focal cerebral ische…
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Zitierempfehlung
O Crome, R Sandau, F Agdas, M Bähr, J Weise (2004) Blood flow independent effects of rt-PA in a model of permanent cerebral ischemia: deterioration of ischemia induced cell death. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833378
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