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Neuron-selective erythropoietin (Epo) overexpression protects against transient focal ischemia and retinal ganglion cell axotomy in mice – role of Akt, Erk-1/2 and Jnk signaling

Ü Kilic, E Kilic, J Soliz, M Gassmann, C Bassetti, D Hermann · Aktuelle Neurologie · Ausgabe 09/2004

DOI 10.1055/s-2004-833379

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Autor:innenÜ Kilic, E Kilic, J Soliz, M Gassmann, C Bassetti, D Hermann
ZeitschriftAktuelle Neurologie
Ausgabe09/2004
Jahrgang / SeitenNicht angegeben

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Background: It has previously been demonstrated that erythropoietin (Epo) protects against focal brain ischemia. Thus, clinical trials in human stroke patients have recently been initiated, which are currently performed. Unfortunately, the underlying mechanisms of action of Epo in vivo are still poorly understood. In order to elucidate this issue, transgenic mice overexpressing Epo in the central nervous system but…

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Ü Kilic, E Kilic, J Soliz, M Gassmann, C Bassetti, D Hermann (2004) Neuron-selective erythropoietin (Epo) overexpression protects against transient focal ischemia and retinal ganglion cell axotomy in mice – role of Akt, Erk-1/2 and Jnk signaling. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2004-833379

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