CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Interferon-gamma acts proapoptotic on Hepatic Stellate Cells (HSC) and abrogates the antiapoptotic Effect of Interferon-alpha by an HSP70 dependant Pathway
DOI 10.1055/s-2005-861581
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Nachweis in CareLit
Autor:innenB Saile, C Eisenbach, J Dudas, G Ramadori
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The activated hepatic stellate cell (HSC) is an important fibrogenic cell type of the liver. Interferon-α (IFN-α) has recently been shown to elicit an antiapoptotic effect on activated HSC by a JAK–2-dependent inhibition of caspase–8 activation. As JAK–2 has so far been shown to be a member of the IFN-γ signal transduction pathway we studied the effect of IFN-γ on apoptosis as well as on its signaling in primary cul…
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Zitierempfehlung
B Saile, C Eisenbach, J Dudas, G Ramadori (2005) Interferon-gamma acts proapoptotic on Hepatic Stellate Cells (HSC) and abrogates the antiapoptotic Effect of Interferon-alpha by an HSP70 dependant Pathway. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2005-861581
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