CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Antagonization of TIMP–1 Induces Apoptosis in Activated Hepatic Stellate Cells
DOI 10.1055/s-2005-861602
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Autor:innenM Roderfeld, R Weiskirchen, S Wagner, ML Berres, C Henkel, J Grötzinger, AM Gressner, S Matern, E Roeb
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: The first pathological implication of chronic toxic liver injury including alcoholism is subsequent cell damage or cell death which results in transdifferentiation of HSC into the myofibroblast phenotype. Activated hepatic stellate cells (HSC) accelerate production of ECM, TIMPs, cytokines, and several MMPs promoting hepatic fibrogenesis. TIMP–1 was found to suppress apoptosis in activated HSC1. Our approach w…
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Zitierempfehlung
M Roderfeld, R Weiskirchen, S Wagner, ML Berres, C Henkel, J Grötzinger, AM Gressner, S Matern, E Roeb (2005) Antagonization of TIMP–1 Induces Apoptosis in Activated Hepatic Stellate Cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2005-861602
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