CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Influence of Glucocorticoids on TGF-β-Smad Signaling in Activated Hepatic Stellate Cells
DOI 10.1055/s-2005-861612
Bibliografische Angaben
Nachweis in CareLit
Autor:innenL Wickert, U Bolkenius, D Hahn, K Breitkopf, AM Gressner
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: The plasma level of corticosteroids in patients suffer from liver fibrosis is elevated as a result of reduced steroid catabolism. TGF- β signaling activates hepatic stellate cells (HSC) and promotes the development of liver fibrosis. Recent studies indicate that glucocorticoids and their receptors seem to antagonize TGF- β effects by interacting with the TGF- β-Smad pathway. However the underlying mechanisms t…
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Zitierempfehlung
L Wickert, U Bolkenius, D Hahn, K Breitkopf, AM Gressner (2005) Influence of Glucocorticoids on TGF-β-Smad Signaling in Activated Hepatic Stellate Cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2005-861612
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