CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The Xenobiotics Transporters Mrp2 (Abcc2) and Bcrp (Abcg2): Basal Expression, Regulatory Events and their Mechanisms in Obstructive Cholestasis are Gender-specific
DOI 10.1055/s-2005-861622
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Autor:innenCG Dietrich, C Gartung, S Matern, A Geier
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Mrp2 (Abcc2) and Bcrp (Abcg2) both are ABC-transporter expressed in the apical membrane of hepatocytes and enterocytes where they restrict uptake and systemic bioavailability of xenobiotics including drugs and carcinogens (Dietrich et al., Gut 2003). Since the extent of (geno-)toxic effects of xenobiotics has widely been shown to be gender-dependent (Ghandi et al., Ann Rev Pharm Tox 2004), we analyzed…
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Zitierempfehlung
CG Dietrich, C Gartung, S Matern, A Geier (2005) The Xenobiotics Transporters Mrp2 (Abcc2) and Bcrp (Abcg2): Basal Expression, Regulatory Events and their Mechanisms in Obstructive Cholestasis are Gender-specific. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2005-861622
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