CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The Histone-Deacetylase Inhibitor SAHA Potentiates Pro-Apoptotic Effects of 5-Fluorouracil and Irinotecan in Hepatoma Cells
DOI 10.1055/s-2005-861632
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Nachweis in CareLit
Autor:innenM Ganslmayer, M Ocker, S Zopf, EG Hahn, C Herold
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Treatment for advanced stages of hepatocellular carcinoma (HCC) remains unsatisfactory. While 5-fluorouracil (5-FU) and Irinotecan are first-line treatment options for other gastrointestinal tumors, the effect on HCCs is low. Previously, histone-deacetylase inhibitors (HDAC-I) like suberoylanilide hydroxamic acid (SAHA) showed anti-tumoral activities in a variety of human cancers in vitro and in vivo. Here, we inves…
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Zitierempfehlung
M Ganslmayer, M Ocker, S Zopf, EG Hahn, C Herold (2005) The Histone-Deacetylase Inhibitor SAHA Potentiates Pro-Apoptotic Effects of 5-Fluorouracil and Irinotecan in Hepatoma Cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2005-861632
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