CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Promotor-Hypermethylation Is Causing Functional Relevant Downregulation of Methylthioadenosine Phosphorylase (MTAP) Expression in Hepatocellular Carcinoma
DOI 10.1055/s-2005-861637
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Nachweis in CareLit
Autor:innenC Hellerbrand, M Mühlbauer, M Schuierer, S Wallner, I Behrmann, F Bataille, J Schölmerich
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Homozygous deletions of human chromosomal region 9p21 occur frequently in several kinds of cancer and are associated with the loss of the tumor suppressor genes p16 (INK4a) and p15 (INK4b). In the same chromosomal region the methyladenosine phosphorylase (MTAP) gene is localised and therefore, may also serve as a tumor suppressor gene. The aim of this study was to analyse MTAP mutations and expression patterns in he…
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Zitierempfehlung
C Hellerbrand, M Mühlbauer, M Schuierer, S Wallner, I Behrmann, F Bataille, J Schölmerich (2005) Promotor-Hypermethylation Is Causing Functional Relevant Downregulation of Methylthioadenosine Phosphorylase (MTAP) Expression in Hepatocellular Carcinoma. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2005-861637
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