CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Mutations within the HCV Genotype 1b NS4B Protein and Correlation to Viral Replication and Initial Viral Kinetics During Interferon-alfa-Based Therapy
DOI 10.1055/s-2005-862309
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Nachweis in CareLit
Autor:innenMW Welker, WP Hofmann, C Welsch, M Albrecht, E Herrmann, M vonWagner, S Zeuzem, C Sarrazin
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2005
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction Treatment failure to interferon (IFN)-based therapy still remains a major problem, especially for hepatitis C virus (HCV) genotype (GT)–1 infected patients. The HCV envelope (E)2 protein, the nonstructural (NS)3, and the NS5A protein have been associated with IFN resistance mechanisms. In the HCV replicon system, the most effective adaptive mutations leading to enhanced viral replication were located wi…
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Zitierempfehlung
MW Welker, WP Hofmann, C Welsch, M Albrecht, E Herrmann, M vonWagner, S Zeuzem, C Sarrazin (2005) Mutations within the HCV Genotype 1b NS4B Protein and Correlation to Viral Replication and Initial Viral Kinetics During Interferon-alfa-Based Therapy. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2005-862309
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