CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
IFN-γ Abrogates Profibrogenic TGF-β Signaling in the Liver by Targeting the Expression of Pathway-Restricted and Inhibitory Smads
DOI 10.1055/s-2005-862314
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Nachweis in CareLit
Autor:innenH Weng, PR Mertens, K Breitkopf, AM Gressner, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
In chronic liver disease, approaches opposing profibrogenic activities of TGF-β may be amenable. According to experimental models IFN-γ counteracts several TGF-β effects. Here, the impact of IFN-γ on hepatic fibrosis in patients with chronic hepatitis B viral (HBV) infection with emphasis on IFN-γ signaling during activation of hepatic stellate cells (HSC) was investigated. In a randomized open-label multicenter tri…
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Zitierempfehlung
H Weng, PR Mertens, K Breitkopf, AM Gressner, S Dooley (2005) IFN-γ Abrogates Profibrogenic TGF-β Signaling in the Liver by Targeting the Expression of Pathway-Restricted and Inhibitory Smads. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2005-862314
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