CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
HMGB-1, the principal mediator of late mortality in sepsis, is downregulated in BLP tolerized THP-1 cells
DOI 10.1055/s-2005-869657
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Autor:innenJ Coffey, L Romics Jr, J Wang, H Redmond
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Bacterial Lipopeptide (BLP) protects against sepsis-related mortality through unknown mechanisms. High mobility group box protein 1 (HMGB1) is the principal mediator of late mortality in sepsis. We postulated that BLP tolerisation may downregulate HMGB1 expression. Methods: Human THP-1 monocytes were tolerised with low-dose BLP (10 ng/ml) prior to BLP stimulation (1000 ng/ml). TNFalpha and IL-6 productio…
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Zitierempfehlung
J Coffey, L Romics Jr, J Wang, H Redmond (2005) HMGB-1, the principal mediator of late mortality in sepsis, is downregulated in BLP tolerized THP-1 cells. Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-2005-869657
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