CareLit · DOI-Nachweis · Aktuelle Neurologie
NSAIDs repress BACE1 gene promoter activity by activation of PPARgamma
DOI 10.1055/s-2005-919211
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Sastre, S Roßner, N Bogdanovic, E Rosen, I Dewachter, P Borghgraef, B Evert, L Dumitrescu-Ozimek, D Thal, G Landreth, J Walter, T Klockgether, F van Leuven, M.T Heneka
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Epidemiological evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) decrease the risk for Alzheimer's disease (AD). Certain NSAIDs can activate the peroxisome proliferator-activated receptor-gamma (PPARg), which is a nuclear transcriptional regulator. Here we show that PPARg depletion potentiates beta-secretase (BACE1) mRNA levels by increasing BACE1 gene promoter activity. Conversely, overexpressi…
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Zitierempfehlung
M Sastre, S Roßner, N Bogdanovic, E Rosen, I Dewachter, P Borghgraef, B Evert, L Dumitrescu-Ozimek, D Thal, G Landreth, J Walter, T Klockgether, F van Leuven, M.T Heneka (2005) NSAIDs repress BACE1 gene promoter activity by activation of PPARgamma. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919211
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