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Homocysteine binds copper and induces COX deficiency and apoptosis in different neuron-like cell culture models preventable by copper supplementation

U Wüllner, H Lutz, E Jarre, S Vielhaber, C Nölker, E Struys, C Jakobs, W Kunz, T Klockgether, M Linnebank · Aktuelle Neurologie · Ausgabe 10/2005

DOI 10.1055/s-2005-919230

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Autor:innenU Wüllner, H Lutz, E Jarre, S Vielhaber, C Nölker, E Struys, C Jakobs, W Kunz, T Klockgether, M Linnebank
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben

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Objective: Severe hyperhomocysteinemia in children with hereditary homocystinuria often presents with a variety of neurological symptoms like mental retardation and seizures, and mild hyperhomocysteinemia has been associated with neurological impairment of the elderly. The causative link of hyperhomocysteinemia and neurological dysfunction is unknown. Methods: We investigated the mechanisms of homocysteine (HCys) ne…

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U Wüllner, H Lutz, E Jarre, S Vielhaber, C Nölker, E Struys, C Jakobs, W Kunz, T Klockgether, M Linnebank (2005) Homocysteine binds copper and induces COX deficiency and apoptosis in different neuron-like cell culture models preventable by copper supplementation. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919230

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