CareLit · DOI-Nachweis · Aktuelle Neurologie
MTX-induced white matter changes are associated with polymorphisms of methionine-metabolism
DOI 10.1055/s-2005-919231
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Linnebank, H Pels, N Kleczar, S Farmand, K Fließbach, H Urbach, K Orlopp, I.G.H Schmidt-Wolf, T Klockgether, U Schlegel
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Objective: CNS demyelination presenting with CNS white matter changes (WMC) in MRI is a typical side-effect of high-dose methotrexate (MTX) chemotherapy. We speculated that the underlying mechanism may be an inhibition of methionine synthesis due to a MTX-induced lack of 5,10-methylenetetrahydrofolate. We studied whether development of WMC in high-dose MTX-treated 42 patients with primary CNS lymphoma (PCNSL) is ass…
Zitieren
Zitierempfehlung
M Linnebank, H Pels, N Kleczar, S Farmand, K Fließbach, H Urbach, K Orlopp, I.G.H Schmidt-Wolf, T Klockgether, U Schlegel (2005) MTX-induced white matter changes are associated with polymorphisms of methionine-metabolism. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919231
Mit CareLit weiterarbeiten