CareLit · DOI-Nachweis · Aktuelle Neurologie
Mutations in the familial Parkinson's disease gene PINK1 enhance the sensitivity to apoptosis induced by proteasomal stress
DOI 10.1055/s-2005-919308
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Autor:innenN Thurow, S Gispert, G Auburger, D Kögel
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Objectives: PINK1 is a putative mitochondrial protein kinase implicated in the pathophysiology of Parkinson's disease (PD). It has recently been shown that mutations in PINK1 are associated with early onset forms of PD. Since proteasome dysfunction and apoptotic cell death seem to play fundamental roles in PD and since mitochondria are crucially involved in apoptosis, we were interested whether 1) familial PINK1 mut…
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Zitierempfehlung
N Thurow, S Gispert, G Auburger, D Kögel (2005) Mutations in the familial Parkinson's disease gene PINK1 enhance the sensitivity to apoptosis induced by proteasomal stress. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919308
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