CareLit · DOI-Nachweis · Aktuelle Neurologie
Genetic analysis of candidate genes modifying the age-at-onset in Huntington's Disease: results of a large European association study
DOI 10.1055/s-2005-919317
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Metzger, P Bauer, J Tomiuk, F Laccone, S DiDonato, C Gellera, H.W Lange, H Weirich-Schwaiger, B Melegh, V Havasi, L Baliko, J.T Epplen, J Zaremba, A Sulek, A.N Basak, E Soydan, J Zidovska, V Kebrdlova, M Pandolfo, P Ribai, L Kadasi, M Kvasnicova, B.H.F Weber, F Kreuz, M Dose, M Stuhrmann, O Riess
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Huntington's disease (HD) is a neurodegenerative disorder, which is caused by an expansion of a polymorphic CAG repeat in the HD-gene encoding huntingtin. There is a strong inverse correlation between the number of expanded CAG repeats in HD patients and the median age-at-onset of HD. Statistical modelling attributes 42–73% of the variance to this single genetic factor. The remainder is determined by other genetic a…
Zitieren
Zitierempfehlung
S Metzger, P Bauer, J Tomiuk, F Laccone, S DiDonato, C Gellera, H.W Lange, H Weirich-Schwaiger, B Melegh, V Havasi, L Baliko, J.T Epplen, J Zaremba, A Sulek, A.N Basak, E Soydan, J Zidovska, V Kebrdlova, M Pandolfo, P Ribai, L Kadasi, M Kvasnicova, B.H.F Webe… (2005) Genetic analysis of candidate genes modifying the age-at-onset in Huntington's Disease: results of a large European association study. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919317
Mit CareLit weiterarbeiten