CareLit · DOI-Nachweis · Aktuelle Neurologie
Interferon beta-1a increases leukocyte TNF-R1 and decreases TNF-R2 gene expression in human MS therapy responders, thus TNF-a signalling via TNF-R1 might be beneficial, via TNF-R2 detrimental
DOI 10.1055/s-2005-919401
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Nachweis in CareLit
Autor:innenR Reuß, S Pohle, K Retzlaff, S Mannes-Keil, C Burger, S Vogel, M Kaps, P Oschmann
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Tissue specifically expressed tumor necrosis factor receptors 1 and 2 (TNF-R1/2) transduce apoptosis or inflammation (Hsu, 1996). In a case, R1 mediates apoptosis in contrast to R2 (Shimizu et al., 2005). Neutralizing TNF-a, e.g. by lenercept, lead to clinical or subclinical relapses. Objective: To investigate the influence of IFN beta-1a on leukocyte TNF-R1 and -R2 gene expression in RR-MS patients. M…
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Zitierempfehlung
R Reuß, S Pohle, K Retzlaff, S Mannes-Keil, C Burger, S Vogel, M Kaps, P Oschmann (2005) Interferon beta-1a increases leukocyte TNF-R1 and decreases TNF-R2 gene expression in human MS therapy responders, thus TNF-a signalling via TNF-R1 might be beneficial, via TNF-R2 detrimental. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919401
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