CareLit · DOI-Nachweis · Aktuelle Neurologie
Different HIV-1 gp120 envelope protein mutants differentially affect calcium responses in cultured cortical astrocytes
DOI 10.1055/s-2005-919425
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Autor:innenR Steinbach, H Schaal, T Nolting, M Schreiber, G Arendt, H Köller
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The HIV-1 envelope glycoprotein gp120 is involved in HIV-1 cell entry. It is released from infected cells within the brain and plays a crucial role in the pathogenesis of HIV- encephalopathy. Depending on its sequence, gp120 binds to alpha (CXCR4)- or beta (CCR5)- chemokine receptors, which are present on neurons, astrocytes and microglial cells. Activation of chemokine-receptors resulted in calcium increase due to…
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Zitierempfehlung
R Steinbach, H Schaal, T Nolting, M Schreiber, G Arendt, H Köller (2005) Different HIV-1 gp120 envelope protein mutants differentially affect calcium responses in cultured cortical astrocytes. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919425
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