CareLit · DOI-Nachweis · Aktuelle Neurologie
GGA1 overexpression alters trafficking and subcellular distribution of the amyloid precursor protein
DOI 10.1055/s-2005-919520
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Nachweis in CareLit
Autor:innenC.A.F von Arnim, I.D Peltan, M Deng, S Courchesne, S.F Lichtenthaler, M.C Irizarry, B.T Hyman
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: The amyloid precursor protein (APP) is cleaved by two sequential proteases, first BACE (beta-site of APP-cleaving enzyme) followed by Gamma-secretase to release the A-beta peptides, that accumulate in the senile plaques in Alzheimer's disease (AD) and the APP intracellular domain (AICD). APP and BACE traffic together. GGA1, a member of the Golgi-localized gamma-ear-containing ARF binding (GGA) protein fa…
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Zitierempfehlung
C.A.F von Arnim, I.D Peltan, M Deng, S Courchesne, S.F Lichtenthaler, M.C Irizarry, B.T Hyman (2005) GGA1 overexpression alters trafficking and subcellular distribution of the amyloid precursor protein. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919520
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