CareLit · DOI-Nachweis · Aktuelle Neurologie
A novel mouse model for spinocerebellar ataxia type 3 containing 148 polyglutamine repeats
DOI 10.1055/s-2005-919551
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Nachweis in CareLit
Autor:innenU Bichelmeier, T Schmidt, J Hübener, J Boy, A Preuß, I Schmitt, J Wilbertz, S Ibrahim, F Laccone, O Riess
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Spinocerebellar Ataxia Type 3 (SCA3) or Machado-Disease (MJD) is an autosomal dominantly inherited neurodegenerative disorder caused by the expansion of a CAG stretch in the MJD1 gene encoding a polyglutamine repeat in the respective Ataxin-3 protein. SCA3 therefore belongs to the group of the so called polyglutamine diseases. In order to study the course of the disease we generated transgenic mouse models for this…
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Zitierempfehlung
U Bichelmeier, T Schmidt, J Hübener, J Boy, A Preuß, I Schmitt, J Wilbertz, S Ibrahim, F Laccone, O Riess (2005) A novel mouse model for spinocerebellar ataxia type 3 containing 148 polyglutamine repeats. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919551
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