CareLit · DOI-Nachweis · Aktuelle Neurologie
3,4-DAA, an orally active synthetic tryptophan catabolite, treats established autoimmune neuroinflammation
DOI 10.1055/s-2005-919610
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Platten, P Ho, S Youssef, H Garren, P Fontoura, R Sobel, M Selley, L Steinman
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Depletion of the essential amino acid tryptophan (Trp) by antigen-presenting cells (APCs) is believed to suppress antigen-specific T cell responses. For instance, inhibition of indoleamine-2,3-dioxygenase (IDO) which is the rate-limiting enzyme in Trp catabolism induces the rejection of tumors and fetal allografts. Thus, IDO appears to play a central role in maintaining T cell tolerance. Using gene microarray analys…
Zitieren
Zitierempfehlung
M Platten, P Ho, S Youssef, H Garren, P Fontoura, R Sobel, M Selley, L Steinman (2005) 3,4-DAA, an orally active synthetic tryptophan catabolite, treats established autoimmune neuroinflammation. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919610
Mit CareLit weiterarbeiten