CareLit · DOI-Nachweis · Aktuelle Neurologie
The pH-dependent effect of mexiletine on IVS4 sodium channel mutants R1448H/C
DOI 10.1055/s-2005-919623
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Nachweis in CareLit
Autor:innenB Mohammadi, K Jurkat-Rott, A Alekov, F Lehmann-Horn, R Dengler, J Bufler
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The effects of extracellular pH (6.2, 7.4 and 8.2) and 0.1mM mexiletine, a channel blocker of the lidocaine type, are studied on two sodium channel mutations of the fourth voltage sensor, R1448H/C. The fast inactivated channel state to which mexiletine preferentially binds is destabilized by the mutations. In contrast to the expected low response of R1448H/C carriers, mexiletine is particularly effective in preventi…
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Zitierempfehlung
B Mohammadi, K Jurkat-Rott, A Alekov, F Lehmann-Horn, R Dengler, J Bufler (2005) The pH-dependent effect of mexiletine on IVS4 sodium channel mutants R1448H/C. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919623
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