CareLit · DOI-Nachweis · Aktuelle Neurologie
Heterozygous R1101K mutation of the DCTN1 gene in a family with amyotrophic lateral sclerosis and frontotemporal dementia
DOI 10.1055/s-2005-919641
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Nachweis in CareLit
Autor:innenC Münch, A Rosenbohm, A.D Sperfeld, I Uttner, S.N Reske, T Meyer, C.O Hanemann, G Stumm, A.C Ludolph
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The molecular mechanisms underlying the co-occurrence of ALS and FTD remain incompletely understood. We report a heterozygous R1101K mutation of the p150 subunit of the molecular motor dynactin (DCTN1) in a family with amyotrophic lateral sclerosis (ALS) and co-occurrence of frontotemporal dementia (FTD). Three members of our kindred were affected with motor neuron disease and two with dementia in an autosomal domin…
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Zitierempfehlung
C Münch, A Rosenbohm, A.D Sperfeld, I Uttner, S.N Reske, T Meyer, C.O Hanemann, G Stumm, A.C Ludolph (2005) Heterozygous R1101K mutation of the DCTN1 gene in a family with amyotrophic lateral sclerosis and frontotemporal dementia. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919641
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