CareLit · DOI-Nachweis · Aktuelle Neurologie
Irradiation and non-lethal hypoxia promote attraction of hematopoietic stem cells towards glioma cells by HIF1-mediated induction of CXCL12
DOI 10.1055/s-2005-919646
Bibliografische Angaben
Nachweis in CareLit
Autor:innenW Wick, R Möhle, B Frank, M Weller, G Tabatabai
ZeitschriftAktuelle Neurologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
We have previously demonstrated that adult hematopoietic stem and progenitor cells (PC) migrate towards glioma cells in vitro and home to experimental gliomas in vivo, stressing the potential of PC as vectors for a cell-based therapy. We defined stromal cell-derived factor-1 (SDF-1/ CXCL12) that is released by glioma cells as the essential chemokine in this process. Because hypoxia is a critical aspect of the microe…
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Zitierempfehlung
W Wick, R Möhle, B Frank, M Weller, G Tabatabai (2005) Irradiation and non-lethal hypoxia promote attraction of hematopoietic stem cells towards glioma cells by HIF1-mediated induction of CXCL12. Aktuelle Neurologie (10). https://doi.org/10.1055/s-2005-919646
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