CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
EGFR-overexpression induces telomerase reactivation in immortalized oral epithelial cells by phosphorylation of the PI3K/AKT pathway
DOI 10.1055/s-2005-919776
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Nachweis in CareLit
Autor:innenS Heeg, G Goessel, M Doebele, M Doebele, M Quante, C Fulda, A von Werder, H Nakagawa, R Beijersbergen, HE Blum
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe04/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Immortalization is closely linked to the maintenance of telomeres either through telomerase activation or alternative lengthening of telomeres (ALT). Oral-esophageal carcinomas frequently involve cyclin D1 overexpression, inactivation of p53 as well as EGFR-overexpression. Following these genetic events, we defined the role of cyclin D1 overexpression, p53 inactivation and EGFR overexpression in immort…
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Zitierempfehlung
S Heeg, G Goessel, M Doebele, M Doebele, M Quante, C Fulda, A von Werder, H Nakagawa, R Beijersbergen, HE Blum (2006) EGFR-overexpression induces telomerase reactivation in immortalized oral epithelial cells by phosphorylation of the PI3K/AKT pathway. Zeitschrift für Gastroenterologie (04). https://doi.org/10.1055/s-2005-919776
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