CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Corticosteroids antagonize TGF-β-Smad signaling in activated hepatic stellate cells
DOI 10.1055/s-2005-919992
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Autor:innenL Wickert, U Bolkenius, D Hahn, N Chatain, K Breitkopf, AM Gressner
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe04/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: TGF-β signaling activates hepatic stellate cells (HSC) and promotes the development of liver fibrosis. Recent studies indicate that glucocorticoids and their receptors seem to antagonize TGF-β effects by interacting with the TGF-β-Smad pathway. However, the underlying mechanisms that mediate corticosteroid-TGF-β-interaction in HSC have not been clarified yet, but might be important for their antifibrotic effec…
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Zitierempfehlung
L Wickert, U Bolkenius, D Hahn, N Chatain, K Breitkopf, AM Gressner (2006) Corticosteroids antagonize TGF-β-Smad signaling in activated hepatic stellate cells. Zeitschrift für Gastroenterologie (04). https://doi.org/10.1055/s-2005-919992
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