CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A monoclonal antibody against murine PlGF blocks primary tumor growth in syngeneic mouse tumor models
DOI 10.1055/s-2005-920121
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Autor:innenC Fischer, M Dewerchin, H Ngo, G Reyns, A Scholz, JM Stassen, H Depraetere, D Collen, L Moons, P Carmeliet
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe04/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Gene targeting studies in mice have elucidated a functional role of placental growth factor PlGF, a homologue of VEGF, in pathological angiogenesis. Loss of PlGF, while not causing any vascular defects during embryonic development, reproduction or normal adult life, impaired angiogenesis in pathological conditions, such as cancer. We generated a neutralizing anti- mPlGF monoclonal antibody which inhibits PlGF bindin…
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Zitierempfehlung
C Fischer, M Dewerchin, H Ngo, G Reyns, A Scholz, JM Stassen, H Depraetere, D Collen, L Moons, P Carmeliet (2006) A monoclonal antibody against murine PlGF blocks primary tumor growth in syngeneic mouse tumor models. Zeitschrift für Gastroenterologie (04). https://doi.org/10.1055/s-2005-920121
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