CareLit · DOI-Nachweis · Zentralblatt für Gynäkologie
Genotyping of Caucasian individuals in the dihydropyrimidine dehydrogenase gene
DOI 10.1055/s-2005-921001
Bibliografische Angaben
Nachweis in CareLit
Autor:innenE Gross, K Seck, S Riemer, R Kates, T Ullrich, V Lutz, N Harbeck, M Schmitt, R Diasio, M Kiechle
ZeitschriftZentralblatt für Gynäkologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Germline mutations in the dihydropyrimidine dehydrogenase gene (DPYD) have been associated with inactivation of the enzyme dihydropyrimidine dehydrogenase (DPD), which is involved in the catabolism of the anticancer drug 5-fluorouracil (5-FU). Loss of DPD appears to be involved in severe drug-adverse effects following administration of 5-FU in cancer patients. We performed a population study to evaluate the frequenc…
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Zitierempfehlung
E Gross, K Seck, S Riemer, R Kates, T Ullrich, V Lutz, N Harbeck, M Schmitt, R Diasio, M Kiechle (2005) Genotyping of Caucasian individuals in the dihydropyrimidine dehydrogenase gene. Zentralblatt für Gynäkologie (10). https://doi.org/10.1055/s-2005-921001
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