CareLit · DOI-Nachweis · Zentralblatt für Gynäkologie
Therapeutic doses of Tamoxifen only partially inhibit the non-genomic effects of Estrogen: Evidence for additive anti-proliferative effect of Tamoxifen with MEK inhibitor
DOI 10.1055/s-2005-921029
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Nachweis in CareLit
Autor:innenS Djahansouzi, T Heimerzheim, M Reinhardt, B Hanstein, P Dall, HG Bender, D Niederacher
ZeitschriftZentralblatt für Gynäkologie
Ausgabe10/2005
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: Data suggests that non-genomic effects of Estradiol (E2) in estrogen-sensitive carcinoma cell lines result in the activation of the MAP-Kinase (MAPK) pathway (p44/42). MAPK activation is a potent proliferative stimulus and E2 activation of this cascade seems to occur rapidly at the plasma membrane. We investigated the interaction of the SERM Tamoxifen (Tam) and a MAPK inhibitor (MEK inhibitor PD98059) on the n…
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Zitierempfehlung
S Djahansouzi, T Heimerzheim, M Reinhardt, B Hanstein, P Dall, HG Bender, D Niederacher (2005) Therapeutic doses of Tamoxifen only partially inhibit the non-genomic effects of Estrogen: Evidence for additive anti-proliferative effect of Tamoxifen with MEK inhibitor. Zentralblatt für Gynäkologie (10). https://doi.org/10.1055/s-2005-921029
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