CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
New role for the hepatocyte during TGF-β mediated liver fibrogenesis
DOI 10.1055/s-2006-931623
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Nachweis in CareLit
Autor:innenK Breitkopf, E Wiercinska, J Hamzavi, L Wickert, AM Gressner, S Kanzler, R Heuchel, MV Singer, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The majority of chronic liver diseases are caused by alcohol and hepatotoxic viruses. These noxes lead to damage of liver cells and release of TGF-β. A central event of this process is transdifferentiation of hepatic stellate cells (HSC). We have previously shown that general hepatic overexpression of the TGF-β antagonist Smad7 abrogates development of experimentally induced fibrosis and inhibits HSC transdifferenti…
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Zitierempfehlung
K Breitkopf, E Wiercinska, J Hamzavi, L Wickert, AM Gressner, S Kanzler, R Heuchel, MV Singer, S Dooley (2006) New role for the hepatocyte during TGF-β mediated liver fibrogenesis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2006-931623
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