CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Crosstalk between glucocorticoid receptor bound corticosteroids and the TGF-β-Smad 3 pathway in liver cells
DOI 10.1055/s-2006-931629
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Nachweis in CareLit
Autor:innenU Bolkenius, D Hahn, AM Gressner, K Breitkopf, L Wickert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: The plasma level of corticosteroids in patients suffering from liver fibrosis is elevated as a result of reduced steroid catabolism. TGF-β signalling activates hepatic stellate cells (HSC) and promotes the development of liver fibrosis. Recent studies indicate that glucocorticoids and their receptors (GR) seem to antagonize TGF-β effects by interacting with the TGF-β-Smad pathway. However, the underlying mecha…
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Zitierempfehlung
U Bolkenius, D Hahn, AM Gressner, K Breitkopf, L Wickert (2006) Crosstalk between glucocorticoid receptor bound corticosteroids and the TGF-β-Smad 3 pathway in liver cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2006-931629
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