CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
MIF and JAB1 enhance TGF-beta signaling in transdifferentiating hepatic stellate cells
DOI 10.1055/s-2006-931654
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Autor:innenR Müller, S Zierow, H Fünfzig, AM Gressner, S Dooley, J Bernhagen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2006
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Hepatic fibrosis is a wound healing process mainly characterized by accumulation of extracellular matrix in response to liver injury. As a consequence of chronic tissue damage hepatic stellate cells undergo a process of transdifferentiation into myofibroblasts. This process is promoted by TGF-beta, a key mediator of fibrosis. The intracellular effectors of TGF-beta signaling, the Smad2/3 proteins, are activated by r…
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Zitierempfehlung
R Müller, S Zierow, H Fünfzig, AM Gressner, S Dooley, J Bernhagen (2006) MIF and JAB1 enhance TGF-beta signaling in transdifferentiating hepatic stellate cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2006-931654
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