CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Inhibitory effects of glucocorticoids on TGF-β-Smad 3 signalling are activated by tauroursodeoxycholic acid in hepatic stellate cells
DOI 10.1055/s-2006-931665
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Autor:innenL Wickert, N Chatain, HD Tauschel, AM Gressner
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2006
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: Tauroursodeoxycholic acid (TUDCA) has a positive effect on cholestatic liver disease especially with autoimmune aspects, which seems to be enhanced by a combination with locally active corticosteroids. TGF-β-Smad 3 signalling activates hepatic stellate cells (HSC) and promotes the development of liver fibrosis. A TGF-β dimer forms a complex with the type II and type I receptor and transduces the signal via Sma…
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Zitierempfehlung
L Wickert, N Chatain, HD Tauschel, AM Gressner (2006) Inhibitory effects of glucocorticoids on TGF-β-Smad 3 signalling are activated by tauroursodeoxycholic acid in hepatic stellate cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2006-931665
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