CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Mouse NTCP is directly transactivated via a conserved HNF-4α element in the proximal promoter region, with further co-activation by PGC-1α
DOI 10.1055/s-2006-931675
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Autor:innenCG Dietrich, N Balasubramaniyan, FJ Suchy, C Gartung, C Trautwein, M Ananthanarayanan, A Geier
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2006
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background & Aim: Sodium taurocholate co-transporting polypeptide (Ntcp), a 50 kDa basolaterally localized membrane transporter, is the major transport system for conjugated bile acids. Induction of cholestasis in rats leads to down-regulation of Ntcp involving decreased HNF–1α binding to a proximal element within the minimal promoter. Mouse Ntcp promoter is missing this proximal HNF–1α element and is activated by a…
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Zitierempfehlung
CG Dietrich, N Balasubramaniyan, FJ Suchy, C Gartung, C Trautwein, M Ananthanarayanan, A Geier (2006) Mouse NTCP is directly transactivated via a conserved HNF-4α element in the proximal promoter region, with further co-activation by PGC-1α. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2006-931675
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